The cell cycle and mitosis are fundamental processes in biology, vital for the growth, development, and maintenance of living organisms. Understanding these concepts is essential for students in the IB Middle Years Programme (MYP) 4-5 Science curriculum, as they form the basis for more advanced topics in cellular biology and genetics. This article delves into the intricacies of the cell cycle and mitosis, providing a comprehensive overview tailored to the educational needs of MYP students.

Key Concepts

The Cell Cycle: An Overview

The cell cycle is a series of events that take place in a cell, leading to its growth, replication, and division into two daughter cells. It is essential for organismal growth, tissue repair, and asexual reproduction. The cell cycle is divided into two main phases: interphase and the mitotic (M) phase.

Interphase: This is the preparatory phase for cell division, consisting of three sub-phases:
- G₁ Phase (First Gap): The cell grows in size, synthesizes proteins, and produces organelles. This phase ensures that the cell has adequate resources for DNA replication.
- S Phase (Synthesis): DNA replication occurs, resulting in the duplication of chromosomes. Each chromosome now consists of two sister chromatids.
- G₂ Phase (Second Gap): The cell continues to grow, produces additional proteins, and prepares the necessary components for mitosis.

Mitosis: The Process of Nuclear Division

Mitosis is the process by which a eukaryotic cell separates its duplicated chromosomes into two identical sets, ensuring that each daughter cell receives an exact copy of the genetic material. Mitosis is subdivided into several distinct phases:

Prophase: Chromatin condenses into visible chromosomes, each consisting of two sister chromatids joined at the centromere. The mitotic spindle, composed of microtubules, begins to form, and the nucleolus fades.
Prometaphase: The nuclear envelope breaks down, allowing spindle fibers to attach to the kinetochores of the chromosomes. Chromosomes begin moving towards the cell's equatorial plane.
Metaphase: Chromosomes align at the metaphase plate (the cell's equator), ensuring that each sister chromatid is attached to spindle fibers from opposite poles.
Anaphase: Sister chromatids are pulled apart by the spindle fibers, moving toward opposite poles of the cell. This ensures that each new cell will receive an identical set of chromosomes.
Telophase: Chromatids reach the poles, decondense back into chromatin, and new nuclear envelopes form around each set of chromosomes. The mitotic spindle disassembles.

The precise regulation of mitosis is crucial for maintaining genetic stability and preventing errors that can lead to diseases such as cancer.

Cytokinesis: The Division of the Cytoplasm

Following mitosis, cytokinesis occurs, which is the physical separation of the cytoplasm into two daughter cells. In animal cells, this involves the formation of a cleavage furrow that pinches the cell into two. In plant cells, a cell plate forms along the center line of the cell, eventually developing into a separating wall. Cytokinesis ensures that each daughter cell receives an appropriate share of the cytoplasm and organelles.

Regulation of the Cell Cycle

The cell cycle is tightly regulated by a series of checkpoints and regulatory proteins to ensure accurate DNA replication and division. Key regulators include:

Cyclins and Cyclin-Dependent Kinases (CDKs): These proteins form complexes that trigger the progression of the cell cycle by phosphorylating target proteins.
Checkpoint Controls: Critical points in the cell cycle where the cell assesses whether to proceed to the next phase. Important checkpoints include:
- G₁/S Checkpoint: Ensures the cell is ready for DNA replication.
- G₂/M Checkpoint: Verifies that DNA replication has been completed successfully.
- Metaphase Checkpoint: Confirms that all chromosomes are properly aligned and attached to the spindle fibers before anaphase begins.

The Importance of the Cell Cycle and Mitosis

Understanding the cell cycle and mitosis is fundamental for comprehending how organisms grow, develop, and repair tissues. It also provides insights into the molecular mechanisms underlying various diseases, including cancer, where cell cycle regulation is disrupted, leading to uncontrolled cell proliferation. Additionally, studying mitosis is essential for fields such as genetics, molecular biology, and medical research.

Abnormalities in the Cell Cycle

Disruptions in the cell cycle can lead to significant cellular abnormalities. Common issues include:

Uncontrolled Cell Division: Can result in tumor formation and cancer progression.
Aneuploidy: An abnormal number of chromosomes in daughter cells, often caused by errors in chromosome segregation during mitosis.
Apoptosis: Programmed cell death can be triggered if severe errors are detected during the cell cycle, preventing the propagation of damaged cells.

Techniques to Study the Cell Cycle and Mitosis

Various laboratory techniques are employed to study the cell cycle and mitosis:

Microscopy: Allows visualization of cells during different phases of the cell cycle and mitosis.
Flow Cytometry: Analyzes the DNA content of cells, providing information about the distribution of cells across different phases.
Fluorescence Microscopy: Uses fluorescent markers to tag specific proteins involved in cell cycle regulation and mitosis.
Molecular Biology Techniques: Techniques such as Western blotting and PCR are used to study the expression of cyclins, CDKs, and other regulatory proteins.

Applications of Understanding the Cell Cycle and Mitosis

Knowledge of the cell cycle and mitosis has several practical applications:

Cancer Research: Identifying targets for cancer therapy by understanding how cell cycle regulation is disrupted in cancer cells.
Genetic Engineering: Manipulating the cell cycle to improve techniques such as gene editing and cloning.
Drug Development: Designing drugs that can specifically inhibit or activate certain phases of the cell cycle to treat diseases.
Regenerative Medicine: Facilitating tissue repair and regeneration by controlling cell proliferation.

Comparison Table

Aspect	Mitosis	Meiosis
Purpose	Growth, tissue repair, asexual reproduction	Production of gametes for sexual reproduction
Number of Divisions	One	Two
Outcome	Two genetically identical daughter cells	Four genetically diverse gametes
Chromosome Number	Diploid (2n) maintained	Halved to haploid (n)
Genetic Variation	No variation (clones)	Genetic variation through crossing over and independent assortment
Phases	Prophase, Prometaphase, Metaphase, Anaphase, Telophase	Prophase I, Metaphase I, Anaphase I, Telophase I, Prophase II, Metaphase II, Anaphase II, Telophase II

Summary and Key Takeaways

The cell cycle comprises interphase and the mitotic phase, regulating cell growth and division.
Mitosis ensures the accurate distribution of duplicated chromosomes into two identical daughter cells.
Regulation of the cell cycle is critical for maintaining genetic stability and preventing diseases.
Comparing mitosis and meiosis highlights their distinct roles in asexual and sexual reproduction.
Understanding cell cycle mechanisms has significant applications in medical research and biotechnology.

Examiner Tip

Tips

Mnemonics for Mitosis Phases: Remembering the order of mitosis phases can be tricky. Use the mnemonic "Please Pass My Apples Today" to recall Prophase, Prometaphase, Metaphase, Anaphase, Telophase.

Visual Aids: Utilize diagrams and animations to visualize each phase of the cell cycle and mitosis, enhancing retention and understanding.

Practice Questions: Regularly attempt practice questions and quizzes to reinforce your knowledge and identify areas needing improvement.

Did You Know

1. During mitosis, the precise alignment of chromosomes ensures genetic consistency, but slight errors can sometimes lead to genetic disorders like Down syndrome.
2. Some organisms, such as certain types of fungi, can undergo mitosis without cytokinesis, resulting in multinucleated cells.
3. The discovery of mitosis dates back to the 19th century, with scientists like Walther Flemming first describing the process using early microscopes.

Common Mistakes

Mistake 1: Confusing mitosis with meiosis.
Incorrect: Believing mitosis produces four daughter cells.
Correct: Mitosis results in two genetically identical daughter cells, while meiosis produces four genetically diverse gametes.

Mistake 2: Overlooking the role of cytokinesis.
Incorrect: Thinking mitosis entirely completes cell division.
Correct: Recognizing that cytokinesis is a separate process that divides the cytoplasm after mitosis.

Mistake 3: Misidentifying phases of mitosis.
Incorrect: Placing anaphase before metaphase.
Correct: Understanding the correct sequence: Prophase, Prometaphase, Metaphase, Anaphase, Telophase.

FAQ

What is the main purpose of the cell cycle?

The main purpose of the cell cycle is to facilitate cell growth, DNA replication, and cell division, ensuring the production of two genetically identical daughter cells for growth, tissue repair, and asexual reproduction.

How does mitosis differ from meiosis?

Mitosis results in two genetically identical diploid daughter cells, primarily for growth and repair. In contrast, meiosis produces four genetically diverse haploid gametes for sexual reproduction, involving two consecutive divisions.

What role do cyclins play in the cell cycle?

Cyclins are regulatory proteins that, in combination with cyclin-dependent kinases (CDKs), control the progression of the cell cycle by phosphorylating target proteins, thereby facilitating the transition between different phases.

What could happen if the metaphase checkpoint fails?

If the metaphase checkpoint fails, chromosomes may not properly attach to the spindle fibers, leading to unequal distribution of chromosomes during anaphase. This can result in aneuploidy and potential genetic disorders.

Why is cytokinesis important after mitosis?

Cytokinesis ensures the physical separation of the cytoplasm and organelles into two distinct daughter cells, completing the cell division process initiated by mitosis.

How is the cell cycle related to cancer?

Cancer often involves disruptions in the cell cycle's regulatory mechanisms, leading to uncontrolled cell division and proliferation. Understanding the cell cycle helps in developing targeted cancer therapies.

1. Electricity and Magnetism

1.1 Magnetic Fields and Electromagnetism

1.1.1 Magnetic Field Around a Bar Magnet

1.1.2 Field Lines Around Currents and Solenoids

1.1.3 Right-Hand Rule and Magnetic Direction

1.1.4 Strengthening Electromagnets

1.1.5 Uses of Electromagnets in Real Life

1.2 Everyday Applications and Safety

1.2.1 Electric Fuses and Circuit Breakers

1.2.2 Earth Wires and Electrical Grounding

1.2.3 Dangers of Overloading and Short Circuits

1.2.4 Household Wiring and Power Ratings

1.2.5 Electricity Safety Rules and First Aid

1.3 Static and Current Electricity

1.3.1 Understanding Static Charge and Discharge

1.3.2 Charging by Friction, Induction, and Conduction

1.3.3 Electric Field Concepts (Introductory)

1.3.4 Hazards and Uses of Static Electricity

1.3.5 Comparison Between Static and Current Electricity

1.4 Series and Parallel Circuits

1.4.1 Constructing Simple Electrical Circuits

1.4.2 Current and Voltage in Series Circuits

1.4.3 Current and Voltage in Parallel Circuits

1.4.4 Advantages and Applications of Each Type

1.4.5 Measuring Current and Voltage with Ammeters and Voltmeters

1.5 Resistance, Voltage, and Current

1.5.1 Ohm’s Law: V = IR

1.5.2 Factors Affecting Resistance

1.5.3 Graphing V-I Characteristics for Resistors and Bulbs

1.5.4 Calculating Resistance in Series and Parallel

1.5.5 Practical Circuits and Energy Consumption

2. Human Body Systems

2.1 Immune System and Diseases

2.1.1 Components of the Immune System

2.1.2 First and Second Line of Defense

2.1.3 Vaccination and Immunity

2.1.4 Pathogens: Bacteria, Viruses, Fungi, and Parasites

2.1.5 Antibiotics, Resistance, and Public Health

2.2 Homeostasis and Regulation

2.2.1 Definition and Importance of Homeostasis

2.2.2 Negative Feedback Mechanisms

2.2.3 Regulation of Body Temperature

2.2.4 Control of Blood Glucose Levels

2.2.5 Disruption of Homeostasis and Disease

2.3 Circulatory and Respiratory Systems

2.3.1 Structure and Function of the Heart

2.3.2 Blood Vessels: Arteries, Veins, Capillaries

2.3.3 Components and Functions of Blood

2.3.4 Structure and Function of the Lungs

2.3.5 Gas Exchange and Role of Alveoli

2.4 Digestive and Excretory Systems

2.4.1 Organs of the Digestive Tract and Their Functions

2.4.2 Mechanical vs Chemical Digestion

2.4.3 Role of Enzymes in Digestion

2.4.4 Absorption in the Small Intestine and Villi

2.4.5 Structure and Function of Kidneys and Nephrons

2.5 Nervous and Endocrine Systems

2.5.1 Structure and Function of the Nervous System

2.5.2 Reflex Arcs and Response to Stimuli

2.5.3 Central and Peripheral Nervous System

2.5.4 Hormones and Their Functions

2.5.5 Comparing Nervous and Hormonal Control

3. Forces and Motion

3.1 Mass, Weight, and Gravity

3.1.1 Distinguishing Mass from Weight

3.1.2 Calculating Weight Using W = mg

3.1.3 Gravitational Field Strength on Earth and Other Planets

3.1.4 Free Fall and the Effect of Gravity

3.1.5 Weightlessness and Orbiting Objects

3.2 Friction, Air Resistance, and Terminal Velocity

3.2.1 Friction: Causes, Effects, and Reduction

3.2.2 Air Resistance and Streamlining

3.2.3 Terminal Velocity in Free Fall

3.2.4 Benefits and Drawbacks of Friction

3.2.5 Applications in Engineering and Sports

3.3 Types of Forces and Newton’s Laws

3.3.1 Types of Forces: Contact and Non-Contact

3.3.2 Newton’s First Law: Inertia and Balanced Forces

3.3.3 Newton’s Second Law: F = ma

3.3.4 Newton’s Third Law: Action and Reaction Pairs

3.3.5 Force Diagrams and Vector Representation

3.4 Balanced vs Unbalanced Forces

3.4.1 Identifying Balanced and Unbalanced Force Scenarios

3.4.2 Motion of Objects Under Balanced Forces

3.4.3 Effect of Unbalanced Forces on Motion

3.4.4 Calculating Net Force in One and Two Dimensions

3.4.5 Friction and Its Role in Balance

3.5 Motion Graphs: Distance-Time and Speed-Time

3.5.1 Interpreting Distance-Time Graphs

3.5.2 Calculating Speed from a Graph

3.5.3 Interpreting Speed-Time Graphs

3.5.4 Calculating Acceleration and Area Under Graphs

3.5.5 Describing Motion Qualitatively and Quantitatively

4. Acids, Bases, and Salts

4.1 Making and Testing Salts

4.1.1 Preparing Soluble Salts Using Different Methods

4.1.2 Using Acid + Base, Acid + Metal, Acid + Carbonate Reactions

4.1.3 Filtering, Crystallizing, and Drying a Salt

4.1.4 Testing Salts for Solubility and Identity

4.1.5 Understanding Solubility Rules for Salts

4.2 Applications of Acids and Bases

4.2.1 Acids in Industry: Cleaning, Fertilizers, Battery Acid

4.2.2 Bases in Everyday Products: Soap, Toothpaste, Drain Cleaners

4.2.3 Role of Acids and Bases in Environmental Chemistry

4.2.4 pH Control in Agriculture and Swimming Pools

4.2.5 Safety and Storage of Corrosive Substances

4.3 Properties of Acids and Bases

4.3.1 Physical and Chemical Properties of Acids

4.3.2 Physical and Chemical Properties of Bases

4.3.3 Common Examples and Uses of Acids and Bases

4.3.4 Laboratory Safety When Handling Acids and Bases

4.3.5 Conductivity of Acidic and Basic Solutions

4.4 pH Scale and Indicators

4.4.1 Understanding the pH Scale (0–14)

4.4.2 Using Litmus, Universal, and Natural Indicators

4.4.3 Strong vs Weak Acids and Bases (Conceptual)

4.4.4 Measuring pH Using Electronic and Paper Meters

4.4.5 Everyday Substances and Their pH Values

4.5 Neutralization Reactions

4.5.1 Definition and Real-Life Examples of Neutralization

4.5.2 Word and Symbol Equations for Neutralization

4.5.3 pH Changes During Neutralization

4.5.4 Applications: Indigestion, Agriculture, Waste Treatment

4.5.5 Heat Changes During Neutralization (Intro to Enthalpy)

5. Genetics and Reproduction

5.1 Variation and Selective Breeding

5.1.1 Sources of Genetic and Environmental Variation

5.1.2 Continuous vs Discontinuous Variation

5.1.3 Artificial Selection in Plants and Animals

5.1.4 Benefits and Risks of Selective Breeding

5.1.5 Natural Selection (Introductory Concept)

5.2 Ethical Issues in Genetics

5.2.1 Genetic Testing and Screening

5.2.2 Genetic Modification and GM Crops

5.2.3 Cloning and Its Controversies

5.2.4 Privacy, Consent, and Use of Genetic Data

5.2.5 Balancing Scientific Progress and Ethics

5.3 DNA Structure and Genetic Inheritance

5.3.1 Structure and Components of DNA

5.3.2 Chromosomes, Genes, and Nucleotides

5.3.3 How DNA Codes for Proteins (Introductory)

5.3.4 Human Genome and Genetic Information

5.3.5 Replication and Genetic Consistency

5.4 Dominant, Recessive, and Co-Dominant Traits

5.4.1 Understanding Dominant and Recessive Alleles

5.4.2 Phenotype vs Genotype

5.4.3 Punnett Squares and Genetic Crosses

5.4.4 Examples of Inherited Traits in Humans

5.4.5 Incomplete and Co-Dominance (Introductory)

5.5 Punnett Squares and Genetic Diagrams

5.5.1 Constructing and Interpreting Punnett Squares

5.5.2 Monohybrid Crosses

5.5.3 Probability and Ratios of Offspring

5.5.4 Predicting Carrier and Affected Individuals

5.5.5 Limitations and Assumptions of Punnett Models

6. Scientific Inquiry and Skills

6.1 Graphing and Data Analysis

6.1.1 Choosing Appropriate Graph Types

6.1.2 Labeling Axes and Using Scale Accurately

6.1.3 Interpreting Line Graphs, Bar Charts, and Pie Charts

6.1.4 Finding Trends and Patterns in Graphs

6.1.5 Using Graphs to Make Predictions

6.2 Evaluating Results and Drawing Conclusions

6.2.1 Analyzing Data to Support or Reject Hypothesis

6.2.2 Sources of Error and How to Reduce Them

6.2.3 Improving Experimental Design

6.2.4 Reliability, Validity, and Repetition

6.2.5 Communicating Scientific Findings Effectively

6.3 Scientific Method and Experimental Design

6.3.1 Steps of the Scientific Method

6.3.2 Formulating Testable Hypotheses

6.3.3 Designing Fair and Controlled Experiments

6.3.4 Variables: Independent, Dependent, Controlled

6.3.5 Distinguishing Between Theory, Law, and Hypothesis

6.4 Measurement, Units, and SI Conventions

6.4.1 SI Base Units and Derived Units

6.4.2 Using Prefixes: milli-, centi-, kilo-

6.4.3 Accuracy, Precision, and Significant Figures

6.4.4 Instrument Selection and Measurement Techniques

6.4.5 Errors and Uncertainty in Measurements

6.5 Data Collection and Recording Techniques

6.5.1 Creating Effective Data Tables

6.5.2 Recording Observations vs Inferences

6.5.3 Use of Tally Marks, Frequency, and Time Logs

6.5.4 Recording Qualitative and Quantitative Data

6.5.5 Safety and Ethical Considerations in Data Gathering

7. Energy and Work

7.1 Heat Transfer: Conduction, Convection, Radiation

7.1.1 Conduction in Solids and Thermal Conductors

7.1.2 Convection in Liquids and Gases

7.1.3 Radiation and Emission of Infrared Energy

7.1.4 Comparing All Three Modes of Heat Transfer

7.1.5 Insulation Techniques and Practical Applications

7.2 Energy Transformations in Real-World Devices

7.2.1 Energy Changes in Light Bulbs, Motors, and Toasters

7.2.2 Energy in Food Chains and the Human Body

7.2.3 Battery to Mechanical Energy Conversion

7.2.4 Identifying Input and Output Energy Forms

7.2.5 Designing Energy-Efficient Systems

7.3 Forms and Conservation of Energy

7.3.1 Different Forms of Energy: Kinetic, Potential, Thermal, etc.

7.3.2 Energy Transformations and Real-Life Examples

7.3.3 Law of Conservation of Energy

7.3.4 Energy Flow in Systems

7.3.5 Useful vs Wasted Energy and Sankey Diagrams

7.4 Work, Power, and Efficiency

7.4.1 Definition and Formula for Work Done

7.4.2 Calculating Power and Energy Transfer Rate

7.4.3 Efficiency = Useful Output / Total Input × 100

7.4.4 Units: Joules, Watts, and Their Conversions

7.4.5 Improving Efficiency in Machines and Devices

7.5 Renewable and Non-Renewable Resources

7.5.1 Types of Renewable Energy Sources

7.5.2 Fossil Fuels and Their Environmental Impact

7.5.3 Advantages and Disadvantages of Energy Resources

7.5.4 Energy Resource Comparison Chart

7.5.5 Global Energy Use and Sustainability

8. Atomic Structure and the Periodic Table

8.1 Periodic Table: Groups and Periods

8.1.1 Structure and Organization of the Periodic Table

8.1.2 Metals, Non-Metals, and Metalloids

8.1.3 Identifying Groups, Periods, and Atomic Number

8.1.4 Group 1: Alkali Metals

8.1.5 Group 17: Halogens and Group 18: Noble Gases

8.2 Periodic Trends and Element Properties

8.2.1 Trends in Reactivity Down Groups

8.2.2 Trends in Atomic Radius, Ionization Energy

8.2.3 Electronegativity Across Periods

8.2.4 Chemical Properties Based on Position

8.2.5 Predicting Properties of Unknown Elements

8.3 Structure of the Atom

8.3.1 Subatomic Particles: Protons, Neutrons, Electrons

8.3.2 Atomic Number, Mass Number, and Nuclear Symbol

8.3.3 Structure of the Nucleus and Electron Shells

8.3.4 Charge and Mass of Subatomic Particles

8.3.5 Development of Atomic Models (Dalton to Bohr)

8.4 Isotopes and Relative Atomic Mass

8.4.1 Definition and Examples of Isotopes

8.4.2 Calculating Relative Atomic Mass (RAM)

8.4.3 Uses of Isotopes in Medicine and Industry

8.4.4 Stability of Isotopes and Radioactivity (Intro)

8.4.5 Representing Isotopes with Notation

8.5 Electronic Configuration and Shell Model

8.5.1 Understanding Electron Shells

8.5.2 Electron Configuration Notation

8.5.3 Rules for Filling Electron Shells

8.5.4 Electronic Configuration of Ions (Intro)

8.5.5 Relating Configuration to Reactivity

9. Ecology and Environment

9.1 Biodiversity and Conservation

9.1.1 Importance of Biodiversity in Ecosystems

9.1.2 Threats to Biodiversity: Habitat Loss, Pollution, Climate Change

9.1.3 Endangered Species and Extinction

9.1.4 Conservation Strategies and Protected Areas

9.1.5 International Agreements on Conservation

9.2 Human Impact and Climate Change

9.2.1 Greenhouse Gases and Global Warming

9.2.2 Carbon Cycle and Human Disruption

9.2.3 Deforestation, Urbanization, and Land Use

9.2.4 Sustainable Practices and Renewable Energy

9.2.5 Climate Action and Global Citizenship

9.3 Ecosystems and Trophic Levels

9.3.1 Definition and Components of an Ecosystem

9.3.2 Producers, Consumers, and Decomposers

9.3.3 Trophic Levels and Energy Transfer

9.3.4 Biomass Pyramids and Energy Pyramids

9.3.5 Limiting Factors and Ecosystem Stability

9.4 Biotic and Abiotic Factors

9.4.1 Definition and Examples of Abiotic Factors

9.4.2 How Biotic Factors Influence Population Size

9.4.3 Adaptations to Environmental Conditions

9.4.4 Interdependence in Communities

9.4.5 Ecosystem Changes Due to Natural and Human Causes

9.5 Food Webs, Pyramids, and Energy Flow

9.5.1 Constructing and Analyzing Food Webs

9.5.2 Energy Loss at Each Trophic Level

9.5.3 Bioaccumulation and Toxins

9.5.4 Ecological Efficiency and Energy Flow

9.5.5 Disruption of Food Webs

10. Cells and Biological Processes

10.1 Enzymes and Metabolism

10.1.1 Structure and Function of Enzymes

10.1.2 Factors Affecting Enzyme Activity

10.1.3 Enzyme Specificity and Active Site

10.1.4 Denaturation and pH/Temperature Effects

10.1.5 Role of Enzymes in Digestion and Respiration

10.2 Energy in Cells: Respiration and Photosynthesis

10.2.1 Word and Symbol Equations for Respiration

10.2.2 Aerobic vs Anaerobic Respiration

10.2.3 Photosynthesis Equation and Factors

10.2.4 Leaf Structure and Adaptations for Photosynthesis

10.2.5 Interdependence of Photosynthesis and Respiration

10.3 Cell Structure and Microscopy

10.3.1 Structure and Function of Animal and Plant Cells

10.3.2 Specialized Cells and Their Adaptations

10.3.3 Differences Between Prokaryotic and Eukaryotic Cells

10.3.4 Using Light Microscopes and Staining Techniques

10.3.5 Calculating Magnification and Image Size

10.4 Cell Division: Mitosis and Meiosis

10.4.1 Cell Cycle and Mitosis

10.4.2 Functions of Mitosis in Growth and Repair

10.4.3 Introduction to Meiosis and Sexual Reproduction

10.4.4 Comparison of Mitosis and Meiosis

10.4.5 Chromosome Behavior and Genetic Continuity

10.5 Diffusion, Osmosis, and Active Transport

10.5.1 Definition and Examples of Diffusion

10.5.2 Factors Affecting Rate of Diffusion

10.5.3 Osmosis in Cells and Living Systems

10.5.4 Active Transport and Energy Requirement

10.5.5 Importance of Transport in Organisms

11. Chemical Reactions and Bonding

11.1 Types of Reactions

11.1.1 Combination and Decomposition Reactions

11.1.2 Single and Double Displacement Reactions

11.1.3 Combustion Reactions (Complete and Incomplete)

11.1.4 Precipitation and Gas Formation Reactions

11.1.5 Observing Chemical Change: Color, Gas, Temperature, Precipitate

11.2 Reactivity Series and Reaction Predictions

11.2.1 Reactivity of Metals with Water, Acid, and Oxygen

11.2.2 The Reactivity Series of Metals

11.2.3 Displacement Reactions Using Metals

11.2.4 Predicting Products Based on Reactivity

11.2.5 Applications of Reactivity in Industry and Everyday Life

11.3 Ionic, Covalent, and Metallic Bonding

11.3.1 Ions and Formation of Ionic Bonds

11.3.2 Properties of Ionic Compounds

11.3.3 Formation and Diagrams of Covalent Bonds

11.3.4 Properties of Covalent Compounds

11.3.5 Structure and Properties of Metallic Bonds

11.4 Chemical Formulas and Equations

11.4.1 Writing Chemical Formulas of Compounds

11.4.2 Word Equations and Symbol Equations

11.4.3 State Symbols in Chemical Reactions

11.4.4 Identifying Reactants and Products

11.4.5 Introduction to Moles and Formula Mass (Optional Extension)

11.5 Balancing Equations and Conservation of Mass

11.5.1 Law of Conservation of Mass

11.5.2 Balancing Simple Chemical Equations

11.5.3 Balancing Complex Reactions with Polyatomic Ions

11.5.4 Mass Changes in Closed and Open Systems

11.5.5 Predicting Products Using Balanced Equations

12. Waves, Sound, and Light

12.1 Electromagnetic Spectrum and Its Uses

12.1.1 Order and Properties of EM Waves

12.1.2 Visible Light and Color Dispersion

12.1.3 Uses of EM Waves: Radio, Microwaves, Infrared, Ultraviolet, X-rays, Gamma Rays

12.1.4 Dangers and Precautions of EM Radiation

12.1.5 Comparing EM Waves: Speed, Wavelength, Frequency

12.2 Light in Communication and Technology

12.2.1 Fiber Optics and Total Internal Reflection

12.2.2 Lasers and Optical Devices

12.2.3 Wave Transmission in Phones and Satellites

12.2.4 Digital vs Analog Signals (Introductory)

12.2.5 Applications of Light and Sound in Modern Tech

12.3 Wave Properties and Types

12.3.1 Definition and Examples of Waves

12.3.2 Transverse vs Longitudinal Waves

12.3.3 Wave Parameters: Wavelength, Frequency, Amplitude

12.3.4 Speed of a Wave: v = fλ

12.3.5 Identifying Crest, Trough, Compression, and Rarefaction

12.4 Sound Waves and Their Behavior

12.4.1 Production and Transmission of Sound

12.4.2 Speed of Sound in Solids, Liquids, and Gases

12.4.3 Echoes, Reflections, and Absorption of Sound

12.4.4 Pitch, Loudness, and Frequency Relationship

12.4.5 Applications: Sonar, Ultrasound, and Musical Instruments

12.5 Reflection and Refraction of Light

12.5.1 Laws of Reflection

12.5.2 Plane, Concave, and Convex Mirrors

12.5.3 Refraction Through Glass Blocks and Water

12.5.4 Lenses: Converging and Diverging (Introductory)

12.5.5 Ray Diagrams and Image Formation Basics

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Cell Cycle and Mitosis

Introduction